Regenerative Medicine

 

MediVet-Amercia Adipose Stem Cell Therapy and Regenerative Medical Therapy – In-House and Available Today!!

Judy and ZoeWhat makes the MediVet-America adipose stem cell therapy technology different? There has been much press and debate over stem cell use and research in the past decade mainly owing to the use of embryonic stem cells.

Stem cells can be classified as either adult origin or embryonic origin and for the time being adult origin bone marrow or fat derived stem cells are the only approved and safe form accepted as viable sources of regenerative cells available. That said there are differing schools of thought as to the best and most efficacious source of mesenchymal stem cells (MSC”s) available within the body.

Most bone marrow advocates turn to a 2009 article in which adipose derived stem cells were found to have marginal effect on regeneration of tissue. Although this was true then it is important to remember that first generation technology was used at that time, unlike the current *5th generation Stromal vascular fractions*(SVF) used in the Medivet stem cell Kits we use in house today.

Blinded Comparison of Cell Counts From the Same Patient

Another important aspect that in my mind makes the Medivet procedure far *superior is the yield *as much as a *60 fold increase in MSC’s* over any other adipose procedure and 100 fold superior to bone marrow derived MSC’s. These cells then are activated or *stimulated with light* to increase viability as well as activity when placed in the effected area.

Finally (as if that was not enough) these cells are *mixed with activated PRP* to produce the most potent SVF available to the veterinarian. Adipose tissue is a much richer source of MSC’s and is proven to be far less invasive with consistently better yields.  Bone marrow requires expansion and wait time and in human and other species is fast loosing ground as the gold standard. It is my belief that in the future this may indeed become the most versatile and widely used therapy in veterinary medicine as we begin to unlock the potential that the body has to heal itself!

 

Stem cell therapy is currently a proven way to improve joint health and well being in many animal species, without the life-threatening side effects of steroids or non-steroidal anti-inflammatory drugs (NSAIDs). Our technology uses either a liposuction or a surgically obtained fat sample from the animal being treated that is processed to separate the stem cells into a concentrated form that is re-injected into their original host. These are NOT embryonic stem cells (that are controversial in human medicine) or stem cells from another animal but simply the animal’s own healing cells in a concentrated and activated form ready to start the healing process with no chance of negative reaction.

Stem cells circulate throughout the body, serving as a source of repair and growth cells for both injury and routine aging. They are found in higher numbers in young animals, migrating to the site of injury to speed up the process of healing. As animals age, these cells become more sedentary and there are fewer stem cells circulating throughout the body. Fat is a very rich source of mesenchymal stem cells, which research is showing are the primary stem cell involved in the healing process. The fat tissue is easily harvested through minor surgery (subcutaneous or abdominal) and in most cases the wound is smaller than a 14-gauge needle. Once the stem cells have been separated and activated, they are injected into the affected joint or area, where they migrate to the area of injury to repair and rebuild the damaged tissue.

20-40 grams of fat are obtained from the animal (20 grams pets – 40 grams from most large animals) and an IN-CLINIC PROCEDURE from Medivet-America is used to isolate the adipose stem cells found within the fat. These cells are then mixed with platelet rich plasma (PRP) from the same animal. This mixture known as the Stromal Vascular Fraction (SVF) is then placed under specific light intensities to hyper-excite these cells and increase their viability. The resulting mixture is returned to the animal within 3-4 hours and the stem cell “Magic” begins to heal, repair and soothe the injury site. These cells begin differentiating into the specific cell types needed as well as the production of many specific growth factors required for healing. This process is proven in rebuilding muscles, bone, ligament, cartilage, and reducing pain and inflammation.

MediVet America Click Here – learn why we use MediVet-America Adipose Stem Cell Therapy technology.

 

Adipose Stem Cell Therapy is the State of the Art method for treating:

  • Hip dysplasia
  • Degeneration or injury to ligament, tendon, muscle or bone
  • Osteoarthritis – including cartilage damage
  • Skin diseases – including Atopy
  • Autoimmune diseases in both dogs and cats and horses
  • Chronic kidney failure
  • Many more

 

SGF 1000

Made from fractionated ovine placental protein extract, it is a formulated combination of growth factors, peptides selected proteins and signaling molecules. The patent pending technology helps to enable the stimulation of trillions of stem cells in vivo from a quiescent (dormant) state to an active state, at significant potency levels never before known to be available. SGF 1000TMhas been designed to assist in internal regeneration and rejuvenation of cells and to help accelerate the repair of organs at the cellular level. Growth factors and peptides proteins assist the repair of organs, damaged and injured muscles, tendons and bone cartilages, nerve tissues, skin tissues and to aid in the total rejuvenation of the body. It is not a drug and chemical free, and when administered by intravenous injection, (by a veterinarian at the desired site), keeps the body’s internal maintenance in check, by activating dormant stem cell reserves, plus the help of growth factors and peptide proteins in supporting the immune system defense.

Veterinary surgeons now have a valuable tool in animal pre and post surgery applications and a unique assistance in intensive care and recovery help of all animals.

 

TB-500

TB-500 is a synthetic version of the naturally occurring Thymosin Beta 4 (Tß4) peptide present in virtually all, human and animal cells. TB-500TM is applied by subcutaneous injection to promote angiogenesis and wound healing. Studies of Tß4 have shown encouraging results regarding its roll in both superficial tissue and skeletal muscle repair. TB-500TM is permitted under the Therapeutic Substance Provision of the United States Equestrian Federation Drugs and Medications Rule.

 

PRP (Platelet Rich Plasma)

PRP, Platelet Rich Plasma, is the platelet concentrated plasma obtained from anti-coagulated whole blood via a centrifugation process. The Platelet concentration needs to be at least four times that of whole blood to be considered “platelet rich”. The platelets are concentrated around the buffy coat, from distal plasma to the uppermost portion of the red pack. PRP is being used clinically by veterinarians for tendon and ligament healing and granulation of tissue defects throughout the US.

 

Other Equine Specific Therapies

IRAP™ 
IRAP therapy utilizes your patient’s own blood and natural healing mechanisms.

How does it work? The IRAP syringe contains specially treated glass beads that stimulate the white blood cells to produce the anti-inflammatory and regenerative cytokines. The whole blood is incubated overnight and then centrifuged to collect serum. The serum produced is then re-injected into the patient.
Has it been tested? The patented IRAP therapy has been used safely and effectively in thousands of horses around the world. In a controlled study at Colorado State University, results indicated that there was significant clinical and histologic improvement in osteoarthritis-affected joints of horses following treatment with autologous conditioned serum (ACS), compared with placebo treatment. Horses treated with ACS had significant clinical improvement in lameness, unlike the placebo group. IRAP therapy has been used to treat a variety of inflammatory conditions: Joint lameness, Tendon and ligament injuries, and Muscle injuries. Information provided by Dechra Veterinary Products.

 

Tildren 
Tildren is a drug for arthritis licensed for use in horses in Europe, and available to veterinarians in the U.S. through special licensure. It has been used in Europe for many years to treat navicular disease and can treat multiple sites of osteoarthritis using an intravenous drip. In addition to treating navicular disease it has also been used to treat horses with hock pain.